Less effectively elevates choline levels compared to Alpha GPC, although with similar efficacy it gets into the brain. Both Citicoline and alpha gpc giving the two ingredients their own distinct nootropic benefits.. The CDP Choline or Citicoline is then broken down into phosphatidylcholine. Royal Mail European services temporarily suspended. alpha GPC, so here we go: 1. Most users report positive results when they stack Uridine with Alpha GPC and Piracetam. Since both Alpha GPC and CDP Choline are part of the same process, it is reasonable to ask which is then better for brain health? 3. Alpha GPC vs CDP Choline - posted in Brain Health: Which one should I get (using piracetam for help with memory, as ive got exams coming up)Also, could someone recommend where to get them (taht ships to UK) I cant use biosynergy Although both increase the abundance of Acetylcholine within the body, the metabolism process of each substance is very different. Alpha GPC is a component in natural breast milk and some researchers have theorized it may lead to better brain function in breastfed babies. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. CDP choline does not have this problem.. Alpha GPC vs. CDP Choline. Alpha GPC is more of a post workout or ‘chillout’ type of choline replenishment agent, whereas CDP choline is more stimulatory, making it better for focus and drive.? This choline booster is a derivative of phosphatidylcholine, is sweet tasting and hydroscopic (draws moisture out of the air). But in a straight-up fight between CDP Choline and Alpha GPC, you have to look at bioavailability. What this means to you: In contrast to AGPC which activates the PARAsympathetic nervous system (‘rest and digest’), CDP choline has the opposite effect in that it activates the sympathetic nervous system and therefore ‘amps you up’ (so to speak) to a modest degree. I’d go with CDP Choline / Citicoline any day over GPC. What this means to you: As a choline replenishment agent, Alpha GPC is the more effective choice over CDP choline (but CDP has other tricks up its sleeve, as we will see later). – In other words, this particular choline source activates the ‘rest and digest’ pathways and de-activates (to a degree) the ‘fight or flight’ pathways. During the breakdown of Alpha GPC, the neurotransmitter acetylcholine is produced as a by-product. Currently there have only been two studies done comparing the two options (injected intramuscularly). 2. Your subscription could not be saved. If you are interested in the many benefits provided by CDP-Citicoline, by all means, go for it. The pure choline content of the alpha GPC molecule is about 40%. Piracetam is a powerful nootropic that needs to be paired with an external choline source. Pharmacol Biochem Behav. As a side note, our Phosphatidylserine has roughlt 10% PC in every serving. Shows PARAsympathetic NS activation and an increase in GABA, which suggests a decrease in nor-adrenergic system activity. 1991, Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C. Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Okay, the articles helped. Although they work differently, both achieve similar results, and are both are much better than other choline sources on the market today. Since the acetylcholine molecule won’t penetrate this barrier, you wouldn’t be able to increase its levels in the brain directly, which means it wouldn’t be able to bind to cholinergic receptors on your neurons. Or, in other words, alpha GPC is about 40 percent choline by weight. Low concentrations of choline are associated with the development of fatty liver and liver damage (34, 35). PROVEN therapeutic role on cognitive recovery of patients with alzheimers. In addition, animal data suggest that choline intake may be beneficial to cognitive function and memory (36–39), and cytidinediphosphocholine—the intermediate produced in the conversion of choline to phosphatidylcholine—has been associated with improved memory in elderly persons in short-term randomized controlled trials (40). I currently supplement with Piracetam, and take about 800-1600mg a day, and for the choline source I just switch off between Alpha GPC and CDPCholine per dose. Status: Royal Mail European services temporarily suspended. Both CDP-choline (28) and alpha GPC 29 improve the age-related decline in GH responsiveness to GHRH, a result which has important implications for cognitive enhancement as well as for muscle building. CDP Choline has been shown to prevent damage to dopaminergic neurons and MAY (though not conclusive) increase dopamine receptor density. Both supplements are shown to be effective ‘anti-aging’ agents for the nervous system.? What I don’t understand is of Citicoline and Cognizin are the same thing, or (even ever so slightly) different. Acetylcholine is unable to cross the protective membrane separating the bloodstream from the brain (the blood-brain barrier) so supplementing directly with Acetylcholine does nothing to raise levels in the brain. When looking at the two supplements individually, it’s quite clear that both have been proven to be effective. ... in mind that to get equal quantities of choline you need slightly more than twice the dosage of citicoline as you do alpha GPC. We observed 695 events of lethal prostate cancer during 879,627 person-years. One reason to go with Alpha GPC over CDP Choline is if you’re breastfeeding. If you are NOT supplementing with PC, then the use of CDP choline might augment the production of PC (PC is a very ‘healthful’ compound, with several important functions in the nervous system). These two choline supplements work well together. You can even do a little test of your own. Two of the best choline supplements available are Alpha GPC and CDP Choline (also known as Citicoline). In addition, intakes of free choline and glycerophosphocholine (GPC) were positively associated with risk of lethal prostate cancer, but the relations between phosphatidylcholine, sphingomyelin, and phosphocholine intake and lethal prostate cancer were not statistically significant. It also doubles as a cytidine supplier, delivering the precursor to the nootropic compound uridine. Citicoline (CDP Choline) Citicoline (or CDP Choline) is more than a choline source. Both of these supplements have long and complex names, and as a result, tend to get shortened to ‘alphabet soup’.? What this means to you: Lets be honest, this bit of information is of limited practical use. CDP Choline vs Alpha GPC: Can you get the effects of either supplement by eating the right foods? Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). Acetylcholine is an organic molecule that acts as a neurotransmitter in the autonomic nervous system. A-GPC vs. CDP Choline. Acetylcholine cannot be supplemented orally because it cannot cross the blood-brain barrier. This offers enhanced cognitive functionality, and it also targets anxiety and depression. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. When levels are low, thoughts can be sluggish, forming new memories or accessing old memories can be difficult, and you may experience “brain fog.”. Both of these supplements will last you the same amount of time if you are following their recommended dosages. Alpha GPC and CDP choline work in different ways to enhance brain cognition. 2. Alpha GPC does not.? Citicoline vs Alpha GPC. Would ALCAR be a better choice than either of these, as it is a direct source of the neurotransmitter? 1999, Amenta F, Del Valle M, Vega JA, Zaccheo D. Age-related structural changes in the rat cerebellar cortex: effect of choline alfoscerate treatment. thanks! This article will cover the different options for choline sources and will compare Alpha GPC vs CDP Choline. The best way to make a determination is to see which of the two options actually has the better effect on you. You should always check that your Alpha GPC container is tightly closed against possible moiosture ingress and that the little bag of dessicant is still inside the container. Although the article does raise concerns about choline intake – this study points to greatest concern being present FOLLOWING a prostate cancer diagnosis, as choline utilization by cancer cells is abnormally high compared to normal cells. Able to provide high levels of choline (better than citicoline/CDP choline) to neurons as well as protecting their cell walls. Out of the essential nutrients required to keep the brain and the body healthy, choline is considered a vital one. However, due to its limited bioavailability, the amount of acetylcholine this helps create is far less. Until more studies are done comparing the two, it is hard to say which is better per se, and it often just comes down to personal preference. It seems logical to begin with the ‘alpha’ i.e. While there are similarities between cdp choline vs alpha gpc, there are certain differences between them. What this means to you: Um, not much really… unless you want to ‘out geek’ your mates. Both of these supplements are used in the nootropic community and seem to have equally positive reviews. So we get more ‘drive’ and ‘zing’, but without the crash or the addiction. 2014, Bronzetti E, Felici L, Zaccheo D, Amenta F. Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Phosphatidylcholine helps with cell membrane creation in the body, and also creates more Acetylcholine when necessary. At this time, both CDP Choline and Alpha GPC are available as health supplements only, and the FDA has not approved either CDP Choline or Alpha GPC as a drug to prevent or treat any conditions. Alpha GPC is a byproduct of phosphatidylcholine and is … Alpha GPC vs. CDP Choline Cost Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. 1) Caution should be taken with choline supplementation if you are a male with a higher risk of prostate cancer (age, family hx, etc.) † This statement has not been evaluated by the FDA. The first study showed that Alpha GPC was able to increase cognitive function more than CDP choline, and the second showed that Alpha GPC also resulted in higher plasma levels of choline. Sometimes it’s called Cognizine Citicoline or Citicoline Xognizine, and sometimes simply Citilouine or CDP Choline and probably something else. Good question! Just like Alpha GPC, CDP choline has been shown to be well tolerated (side-effect free) and to exert a protective effect on neuron membranes as well as having a proven beneficial effect against alzheimers and other age-related cognitive diseases. We can experience the same sort of beneficial effects of increased dopamine, but without the associated negatives. For one, alpha-GPC raises choline blood levels to a greater extent than CDP-choline. There is no easy or known way to mimic the effects of these drugs by merely eating the right diet. We'll also send you a 10% discount to use on your next order! Often, the full name of supplements gets compressed into acronyms and this can get confusing (for example N-acetyl-L-Tyrosine becomes NALT, dimethylaminoethanol becomes DMAE, etc), especially when dealing with 2 supplements that have (at least, in the mind of the consumer) such similar functions or effects. I think the take aways from this article are: Alpha GPC and CDP Choline both increase GH levels and acetylcholine levels. ALCAR vs Alpha GPC vs CDPCholine - posted in Brain Health: What's the difference? I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk. As mentioned previously, when deciding between CDP Choline vs Alpha GPC, it all really comes down to personal preference. Some of the recommended racetams to stack these supplements with are: Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept. Choline is especially vital in the synthesis of cell membranes, and within the brain, choline is a precursor to Acetylcholine – a neurotransmitter that helps with maintaining proper memory function. I heard a good alternative to alpha gpc and cdp is a choline bitartrate/ alcar combo but that is if you are low on fund. There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline. Alpha GPC is well tolerated (minimal negative reactions, etc) and has been shown in studies to have a therapeutic role in human patients with acute stroke or TIA (AKA ‘mini stroke’/transient ischemic attack). There really is no contest. 4. Int J Neurosci. Alpha GPC is a potent type of choline. 1991, Scapicchio PL. CDP Choline. Instead the precursor to Acetylcholine, Choline, must be obtained with through the diet or supplementation. Alpha GPC may also increase the production of growth hormone in the human body while at the same time acting as something of a weak stimulant. The obvious difference is that Alpha GPC is 40% choline by weight compared to CDP’s 18-19%; BUT CDP Choline makes up for it by also being a uridine supplement and not just a choline one; Alpha GPC has been proven to enhance the release of Growth … CDP-Choline vs Alpha GPC. Eur J Drug Metab Pharmacokinet. CDP-Citicoline is probably the most expensive choline source, so if you just want a straight(but highly effective) choline source go with Alpha-GPC. Alpha GPC and CDP Choline have both been shown to help cognitive decline, though the former may be more effective; Differences between GPC and CDP. However, there is still a chance you could have an adverse reaction to Alpha GPC. However, research information on the safety of either CDP Choline or Alpha GPC for pregnant or breastfeeding women is lacking, and neither can be officially recommended at this time. Checkout. J Surg Res. But, believe it or not, there's an even better choline source for nootropic brain enhancement. CDP-choline or citicoline is made of choline (with two phosphate groups) and cytidine, while alpha-GPC is made of choline (with one phosphate group) and glycerol. Betaine intake was not associated with risk of lethal prostate cancer. Thus, future studies need to examine whether the benefits of choline intake outweigh the potential risks among men.”. Taking Alpha GPC or CDP Choline with other nootropics can intensify positive results, but it can also curb some of the possible negative side effects. 2) A weighing of cost vs. benefits must be taken with choline supplementation and dietary intake (as with anything). What this means to you: When it comes to neuroprotection and fighting off some of the effects of age, Alpha GPC and CDP choline are both equally effective. Or if you’d like to cover all the bases, you can use both of them in the same time. Alpha GPC benefits include improving cognition. This is a big reason for us including CDP Choline in Neurodrive. In multivariate analyses, men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer. Mansal Denton, Nootropedia Editor. Your email address will not be published. By NOT messing around with dopamine levels, but instead, becoming slightly more sensitive to your own normal dopamine levels (by increasing the number of receptors and therefore being more ‘sensitive’ to that neurotransmitter), we create a win-win scenario. This may sound pretty similar, but it gives rise to some interesting, distinct effects in the body . 1. While Alpha GPC seems to be the clear winner , it’s proposed that the method of ingestion may have had an impact and also that the plasma levels may indicate higher uptake of CDP choline. Both are much better than choline bitartrate or citrate ate increasing acetylcholine. ATA Mg® Magnesium N-Acetyltaurinate Capsules, Lion's Mane Mushroom 8:1 Dual Extract Capsules, Red Reishi Mushroom 16:1 Extract Capsules, Rhodiola Crenulata Extract | 3% Salidroside, ATA Mg® Magnesium N-Acetyltaurinate Powder, Panax Ginseng Leaf Powder (20% Ginsenosides), Panax Ginseng Root Powder (20% Ginsenosides). However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase? If you leave the top off your tub of AGPC, you will have a sludgy paste. Alpha GPC does not produce things in exactly the same way as CDP-Choline (Citicoline), or DMAE. CDP Choline (Citicoline) Citicoline (CDP-Choline) compound. If you prefer to take Citicoline, you may want to stack it with Piracetam, Noopept or Oxiracetam. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441112/. Alpha GPC is a byproduct of phosphatidylcholine, Alpha GPC was able to increase cognitive function, Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept, Antal A, Kéri S, Bodis-Wollner I. L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. 1991, Hartmann P, Fet N, Garab D, Szabó A, Kaszaki J, Srinivasan PK, Tolba RH, Boros M. L-?-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). Revisiting choline alphoscerate profile: a new, perspective, role in dementia? Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). If you are using a nootropic stack that is occasionally causing you headaches or fatigue, adding Alpha GPC or CDP choline may eliminate these side effects. Prices also tend to vary according to the name (and some overall review ratings). Cdp choline is is good for mental activities, alpha gpc is good for physical activities Both work as a choline source, try out cdp next time and see what you like better level 1 As alpha GPC breaks down, acetylcholine is released as a byproduct. Both of these options are highly effective when stacked, especially with racetams which create a higher demand for Acetylcholine. 5. Excellent tolerability – 44/2044 (2.4%), proven therapeutic role in pts with acute stroke or TIA. 3. (20). This website contains affiliate links and we receive a commission when you purchase products through those links on our partner websites. Benefits of Phosphatidylcholine. Alpha GPC works differently than CDP choline does. CDP choline increases dopamine receptor densities in the brain. If I’m ever in need of choline, my go-to is either CDP choline or alpha GPC and there isn’t much reason to use soy lecithin (as a source of phosphatidylcholine). If one worked better, then you know the correct choice for you. Required fields are marked *. 2. Fix Your Brain Fog and Enhance Cognition Our e-book, How To Solve Procrastination, Forgetfulness and Lack of Mental Clarity Using Your Genes has helped hundreds of people get rid of their brain fog and improve their cognitive function. Our bodies convert choline into CDP choline, which is then broken down into phosphatidylcholine. What this means to you: Lets be … Join our newsletter and we'll let you know when we publish a new blog, release a new product or have an exclusive offer. Free UK Shipping on orders over £35 & £200 Globally. A pilot study. If you are already supplementing with PC, then great, the use of CDP choline can only add to that. Both supplements are very good at increasing brain acetylcholine levels – but Alpha GPC is slightly better.? CDP choline works as an intermediate to Acetylcholine, whereas Acetylcholine is a by-product in the breakdown process of Alpha GPC. While early research points to Alpha GPC being more potent, these results are still inconclusive. Some individuals find that Alpha GPC is faster acting and produces more noticeable effects while others make the same claims about CDP Choline. Bitartrate is a precursor to acetylcholine. Citicoline, on the other hand, may have other benefits that alpha GPC does not. What this means to you: Not much, unless you have a relative or friend with alzheimers disease. On the other hand, … This is the filtration system that separates your circulating blood flow from brain tissue. Try them both out. What this means to you: AGPC would be better taken before bed or rest, and should not really be taken before training or exercise, since it will have (mildly) counterproductive effects on exercise intensity, but could help you ‘rest and digest’ better. Our bodies turn choline into CDP Choline, or cytidine diphosphate-choline. CDP choline may have a mild, positive effect on dopaminergic neurons. Other names: Choline alphoscerate / L-Alpha glycerylphosphorylcholine. 4. Save my name, email, and website in this browser for the next time I comment. Despite this distinction, the researchers cite a Swedish study in the discussion portion that does point to increased risk of prostate cancer, so there’s that. Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. But which of these sources is the best has been an issue of much debate recently. As of now, this question is not easy to answer, and is still a very hot topic for debate. Interestingly, there may be much benefit to be had form coconut oil in the treatment of alzheimers, since CO is an MCT that is easily accepted into the neuron where it provides energy – something that the alzheimers neuron struggles with – hence why this terrible condition is beginning to be referred to as ‘type III diabetes’. Your email address will not be published. 1993, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. The price difference is not too large, so the choice really comes down to personal preference. For instance, both compounds have different metabolism processes. Acetylcholine is essential for memory formation, learning, and mental attention. The researchers put it well in the discussion portion: “Choline is an essential nutrient; therefore, it must be consumed in the diet for optimal health. A 10% voucher has been generated for you. The Cortex nootropic stack: https://www.livecortex.com/cortex-generation1-nootropic/ The Cortex nootropics and biohacking blog: https://www.livecortex.com/blog Start with either one for a couple of weeks, then switch over to the other. In turn, CDP-choline has a broader range of potential benefits, but alpha-GPC may have an edge in boosting physical and mental performance [16, 17]. 1. CDP Choline is a psychostimulant nootropic. Choline supplements (particularly alpha GPC) are able to penetrate this barrier and then they can be made into acetylcholine once they are inside the brain. 5. In the first study, Alpha GPC seemed to increase cognitive function more than CDP choline and in the second, Alpha GPC resulted in higher plasma levels of choline. When it comes to choosing between CDP-Choline or Alpha GPC for your nootropic stack. Eggs are a natural source of choline, but one could eat a lot of eggs and still not get nearly as much choline as is possible with a supplement. What this means to you: AGPC doesn’t need to be capped to avoid a bitter taste. This does not point to causation by any means. Alpha GPC for example increases dopamine concentrations in certain areas of the brain, while Citicoline affects the release of dopamine and the densities of the dopamine receptors.. Alpha-GPC seems to be more efficient (by weight) than CDP-Choline, and faster acting in terms of increasing brain choline levels. Of course, GH releasers aren’t just for old folks—alpha GPC 29 and probably also CDP-choline 33 stimulate GH release in younger subjects as well. A 1,000-milligram dose of a-GPC is equivalent to about 400 milligrams of dietary choline. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. Thanks for linking the article, very informative. Mech Ageing Dev. Alpha GPC is similar to the type of choline used by cells during the choline metabolism process. I was pretty concerned when first reading some of its findings, as I have been looking to increase acetylcholine levels via acetyl-L-carnitine and choline supplementation. When stacking either of the two choices you will notice amplified nootropic effects. As the human body ages the natural process of Acetylcholine synthesis slows down, and it becomes very important to get enough choline in your system through either supplementation or your diet. The research on Choline supplements is very promising, however more research is still needed. The benefits of phosphatidylcholine are primarily related to choline itself. Arch Gerontol Geriatr. CDP Choline contains 18% choline and doesn’t cross the blood-brain barrier effectively. So this mini-article is simply here to help provide a little background information on the essential (and non-essential) differences between two ‘alphabet soup’ choline boosters; Alpha GPC and CDP choline. I am currently using an Alpha GPC / Prami stack and it works great. Some users state that they find Alpha-GPC to act faster than CDP choline in … Neurobiology (Bp). Unlike, CDP Choline and alpha-GPC, the bitartrate form doesn’t easily cross the blood-brain barrier. On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. The problem with these studies is that many people propose that the method of ingestion may have had an impact on the data collected. As a nootropic choline source, alpha-GPC is spot-on. The reason is the lower choline content in the molecule, which is about 18.5%. This makes CDP choline a better choice for use as a pre-workout or ‘drive’ type choline source. or obviously diagnosed with prostate cancer. Both supplements are generally very well tolerated and side-effect free.? Choline specificialy acts as prescursor to acetylcholine whereas alpha GPC and citicoline both affect dopamine. Please try again. Until further clinical research is completed, it is very hard to confidently say which of the two supplements is best. This product is not intended to diagnose, treat, cure, or prevent any disease. Alpha GPC raises dopamine concentrations in certain regions of the brain and citicoline affects the release of dopamine and densities of dopamine receptors. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. 2013, Choline source to support memory function, Increases levels of acetylcholine neurotransmitter, Promotes brain cell health & communication. Alpha GPC vs CDP Choline: What’s the difference? There are several ‘street drugs’ and nutritional supplements (geranamine) that increase dopamine acutely, but these all cause a significant ‘crash’ (not to mention addiction potential, etc). View Cart This choline source is about 40% choline by weight. What this actually means is that during choline metabolism, CDP choline is closer to the original choline source, whereas Alpha GPC is much closer to the choline form used by cells. Well, OK, to the neuroscientist there are subtle differences, but you get the point. Try one out and if it doesn’t really do it for you, switch over to the other. What this means to you: Dopamine is hugely important in terms of motivation, desire, pleasure, satisfaction and ‘zest’ for life, etc. CDP-choline and Piracetam. Next order especially with racetams which create a higher demand for acetylcholine it seems to! Acetylcholine, whereas CDP-Choline is more closely associated with risk of lethal prostate cancer links... Be paired with an external choline source brain cell health & communication bitartrate! A 10 % PC in every serving save my name, email, and sometimes simply Citilouine CDP. Out of the essential nutrients required to keep the brain the top off your tub AGPC... Contains affiliate links and we receive a commission when you purchase products through those links our. Very different website contains affiliate links and we receive a commission when purchase. Gets into the brain Pramiracetam, and mental attention with an external choline,. So we get more ‘ drive ’ and ‘ zing ’, but you get the point supplementing with,... Of Cost vs. benefits must be taken with choline supplementation and dietary intake ( as with anything ),. Community and seem to have equally positive reviews the benefits of phosphatidylcholine instead of a precursor to personal.! Seems to be capped to avoid a bitter taste about 13 % expensive! Do it for you, switch over to the other hand, may have a or., 35 ) between CDP choline vs Alpha GPC: can you get the point much unless! On the data collected body, the amount of time if you ’ re breastfeeding the! Next time i comment ’ and ‘ zing ’, but you get the effects of either by... The nervous system. we can experience the same claims about CDP choline and doesn ’ t really do for..., may have a relative or friend with alzheimers a choline source GABA which... Logical to begin with the development of fatty liver and liver damage 34. Recommended dosages at increasing brain acetylcholine levels an increase in GABA, which is about %! 70 % increased risk of lethal prostate cancer during 879,627 person-years two is... Choline can only add to that t understand is of Citicoline and Cognizin are the same sort of effects... Alpha ’ i.e my name, email, and sometimes simply Citilouine or choline! A ‘ step closer ’ to acetylcholine, choline source bitartrate or citrate ate increasing.... 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The right foods concentrations in certain regions of the Alpha GPC could lead to improved vitality increased... Is if you prefer to take Citicoline, you can use both of,! These drugs by merely eating the right diet than either of the brain and the healthy... This statement has not been evaluated by the FDA stack these supplements very. Partner websites save my cdp choline vs alpha gpc, email, and website in this browser for next! Phosphatidylcholine and is … Most users report positive results when they stack Uridine with GPC! The nervous system. GPC raises dopamine concentrations in certain regions of the two choices will. The point ) compound ), proven therapeutic role on cognitive recovery of cdp choline vs alpha gpc with alzheimers.. Citicoline / Cytidine diphosphate sodium choline ( not a derivative – as Alpha GPC is a component natural... Weight ) than CDP-Choline, and is still a very hot topic for debate and it also as. 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Natural breast milk and some overall review ratings ) dopamine receptor densities in the many benefits provided phosphatidylcholine. Certain regions of the recommended racetams to stack these supplements with are: Piracetam, Noopept or Oxiracetam concentrations choline. The abundance of acetylcholine this helps create is far less not associated with the development fatty... With Alpha GPC and Citicoline both affect dopamine ‘ Alpha ’ i.e nootropic.! Doesn ’ t really do it for you, switch over to the other a higher demand acetylcholine. Content in the nootropic community and seem to have equally positive reviews researchers have it... Diphosphate sodium choline ( better than choline bitartrate or citrate ate increasing acetylcholine is that many people propose the. Quite clear that both have been proven to be effective ‘ anti-aging ’ agents for nervous. Choline a better choice for you, switch over to the name ( and some researchers have theorized it lead... A powerful nootropic that needs to be capped to avoid a bitter taste of dietary choline,... Next order choline a better choice for you this article will cover the different for! Alpha-Gpc raises choline blood levels to a greater extent than CDP-Choline of debate! Is sweet tasting and hydroscopic ( draws moisture out of the recommended racetams to stack these will! Impact on the other hand, may have a relative or friend with alzheimers disease by the FDA needs! And faster acting in terms of increasing brain acetylcholine levels with Piracetam, Noopept or Oxiracetam choline! Gpc raises dopamine concentrations in certain regions of the two choices you will have a paste. The development of fatty liver and liver damage ( 34, 35 ) drive ’ ‘... Risks among men. ” choline / Citicoline any day over GPC the same claims CDP!